Artocarpus altilis (Fouyapen) : medicinal properties in alcoholic extraction

Artocarpus altilis (Fouyapen) — family Moracées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The monograph draws on 34 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Stem.
   According to Hsu (2010): Cytotoxic effects of geranyl flavonoid derivatives from the fruit of Artocarpus communis in SK-Hep-1 human hepatocellular Carcinoma, Food Chem. According to Arung TE (2009): Anticancer Properties of Diethyether Extract of Wood from Sukun (Artocarpus altilis) in Human Breast Cancer (T47D) Cells, Trop J of Pharmaceut Res, 2009, 8(4) 317-24.
2. High blood pressure, oedema, fluid retention : Plant part used: Sheet.
   According to Kingsley AI (2014): This study therefore evaluated the anti-inflammatory activity, as well as the antioxidant potential of an ethanol stem bark extract of A altilis. Per the findings, the ethanolic stem bark extract of AA exhibits anti-inflammatory & antioxidant activities & therefore gives credence to it use in folklore medicine. According to Juliastuti H (2017): Liver disease including hepatitis & hepatotoxicity require proper management so they may Heal faster.
3. Fever, malaria (Plasmodium), : Plant part used: Stem. Documented pharmacological profile: Chloroquine-Pyrimethamine-like.
   According to ADEBAJO AC (2013): altilis stem bark were investigated for prophylactic, chemosuppressive and curative antiplasmodial activities using Plasmodium berghei b infected mice (Peters, 1967; Ryley & Peters, 1970). The standard drug chloroquine gave ED50, ED90 of 2.19 ± 0.10; 4.29 ± 0.1 and 2.16 ± 0.02; 4.14 ± 0.02 mg/kg for the chemo suppressive and the curative test respectively, while Pyrimethamine gave 0.45 ± 0.11 and 0.91 ± 0.11 mg/kg for the prophylactic test.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo from the Traditional Martinique Pharmacopoeia.