Citron limon (Sitwon-frans) : medicinal properties in alcoholic extraction

Citron limon (Sitwon-frans) — family Rutacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The monograph draws on 83 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Fruit. Documented pharmacological profile: Capecitabine-like.
   According to Anandakumar P (2021): This review provides worthy information about the beneficial effects of D-limonene such as antioxidant, antidiabetic, anticancer, anti-inflammatory, cardioprotective, gastroprotective, hepatoprotective, immune modulatory, anti-fibrotic, anti-genotoxic etc. According to Manthey JA (2001): Each of these groups of compounds exhibits a number of in vitro & in vivo anti-inflammatory & anticancer actions. The citrus flavonoids extend their influence in vivo through their induction of hepatic phase I & II enzymes, & through the biological actions of their metabolites.
2. Liver disorders : Plant part used: Fruit. Documented pharmacological profile: Silymarine-like.
   According to Mahmoud MF (2014): Limonin ameliorated the deleterious effects of I/R as indicated by improvement in liver function tests. Limonin has been shown to exhibit anti-inflammatory & antioxidant properties in the settings of chemically induced hepatic injury. According to Boye A (2024): limon) in preventive & curative treatment of many cancers including liver cancer.
3. Oxidative stress : Plant part used: Fruit. Documented pharmacological profile: Acide ascorbique-like, Rutin-like.
   According to Wang Y (2022): Citrus flavonoids play an essential role in regulating oxidative stress & are an important source of daily intake of antioxidant supplements. The antioxidant ability is the link & bridge connecting a variety of biological activities. According to Martí N (2009): Their antioxidant activity & related benefits derive not only from VC but also from other phytochemicals, mainly flavonoids.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Syrio without modification (CC BY 4.0). License : CC BY 4.0.