Citrus aurantium (Zoranj-anmè) : medicinal properties in alcoholic extraction

Citrus aurantium (Zoranj-anmè) — family Rutacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The monograph draws on 138 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Convulsion, epileptic fit : Plant part used: Flower. Documented pharmacological profile: Diazepam-like.
   According to Hosseini M (2011): The duration of tonic convulsion (a tonic extension of the hind limb) was recorded. The animals of groups 1 & 5 received saline (10 ml/kg) a&diazepam (3 mg/kg) respectively, instead of extract. According to Azanchi T (2014): The anticonvulsant activity of neroli was assessed in pentylenetetrazole (PTZ)-induced convulsion by i.v.
2. Cancer : Plant part used: Fruit peel.
   According to Odeh F (2012): subspamara peels on a colorectal cancer cell line (Lim1863). In conclosion, CA peels Eos obviously reduced the cell viability & it might have cytotoxic effect against colorectal cancer cell line. According to Goo L (2022): We demonstrated its application for isolation of phenolic compounds with anti-proliferative activity against colorectal cancer cells (CRCs) from Citrus aurantium L.
3. Liver disorders : Plant part used: Fruit peel. Documented pharmacological profile: Silymarine-like.
   According to Lim SH (2016): Mice were sacrificed & liver fibrosis was evaluated by serum & hepatic tissue biochemistry & liver histopathological examination. To evaluate the possible protective effect of Citrus aurantium peel extract (CAE) against apoptosis in cholestatic liver fibrosis induced by bile duct ligation in mice. According to Pallavi M (2021): Remarkably, lime peel extract followed by sour orange & orange at 500 mg kg-1 dose improved hepatic architecture to near normal with less deposition of fat globules & fewer sinusoids.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by A. Barra without modification. License : CC BY-SA 4.0.