Citrus x (Sitwon-frans) : medicinal properties in alcoholic extraction

Citrus x (Sitwon-frans) — family Rutacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The monograph draws on 83 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Liver disorders : Plant part used: Fruit. Documented pharmacological profile: Silymarine-like.
   According to Mahmoud MF (2014): Limonin ameliorated the deleterious effects of I/R as indicated by improvement in liver function tests. Limonin has been shown to exhibit anti-inflammatory & antioxidant properties in the settings of chemically induced hepatic injury. According to Anandakumar P (2021): This review provides worthy information about the beneficial effects of D-limonene such as antioxidant, antidiabetic, anticancer, anti-inflammatory, cardioprotective, gastroprotective, hepatoprotective, immune modulatory, anti-fibrotic, anti-genotoxic etc.
2. Cancer : Plant part used: Fruit. Documented pharmacological profile: Capecitabine-like.
   According to Anandakumar P (2021): This review provides worthy information about the beneficial effects of D-limonene such as antioxidant, antidiabetic, anticancer, anti-inflammatory, cardioprotective, gastroprotective, hepatoprotective, immune modulatory, anti-fibrotic, anti-genotoxic etc. According to Cirmi S (2017): Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation. Objective: To summarize the numerous evidences on the potential of Citrus juice & their extracts as anticancer agents.
3. Oxidative stress : Plant part used: Fruit. Documented pharmacological profile: Acide ascorbique-like, Rutin-like.
   According to Wang Y (2022): Citrus flavonoids play an essential role in regulating oxidative stress & are an important source of daily intake of antioxidant supplements. The antioxidant ability is the link & bridge connecting a variety of biological activities. According to Martí N (2009): Their antioxidant activity & related benefits derive not only from VC but also from other phytochemicals, mainly flavonoids.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Syrio without modification (CC BY 4.0). License : CC BY 4.0.