Clitoria ternatea (Blue wheat) : medicinal properties in alcoholic extraction

Clitoria ternatea (Blue wheat) — family Convolvulacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 34 indications in alcoholic extraction for this species. The monograph draws on 179 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Sheet. Documented pharmacological profile: Staurosporine-like.
   According to Alshamrani MS (2022): The goal of this work was to examine the antiproliferative role of Clitoria ternatea against colorectal (HCT116), breast (MCF-7), & thyroid (TT) cancer cell lines at cellular & molecular levels. This study concluded that an ethanolic extract of CT induced apoptotic cell death, suggesting that it could possibly be utilized as a new source of an apoptosis-inducing anticancer agent for colon, breast, & medullary thyroid cancer cell line treatments with further detailed studies.. According to Asysyifa A (2020): Methods: Maceration process using 96% ethanol to obtain the crude extract, thin layer chromatography (TLC) to see the phytochemical profile of CT leaf extract, MTT assay to determine the IC50 using log probit analysis as a reference for the next test which is scratch wound healing assay to assess the effect of CT leaf extract on the migration of 4T1 breast cancer cell line.
2. Neurodegenerative disorder : Plant part used: Sheet. Documented pharmacological profile: Pyritinol-like, Piracetam-like.
   According to Lee RX (2021): ternatea have been previously studied for its neuroprotective properties linked to memory enhancement of the mammalian brain, indirectly delaying the occurrence of neurodegenerative diseases. According to Damodaran T (2018): Conclusions: Our findings demonstrated an improving effect of CT root extract on memory in the CCH rat model suggesting that CT root extract could be a potential therapeutic strategy to prevent the progression of cognitive deterioration in vascular dementia (VaD) & Alzheimer's disease (AD) patients.
3. Type II diabetes mellitus : Plant part used: Seed. Documented pharmacological profile: Glibenclamide-like.
   According to Rusmana D (2024): Rats suffering from diabetes will be examined after being given oral doses of Simvastatin 0.9 mg/kg BW, Glibenclamide 0.45 mg/kg BW, & 200, 400, & 800 mg/kg BW CTE, model induced by streptozotocin. Metabolic abnormalities caused by the accumulation of human, environmental, genetic & lifestyle variables can be found in diabetes mellitus (DM). According to KUMAR TA (2013): The results indicated that EECT has remedial effects on hyperglycemia and oxidative stress in diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Carlos E. Perez S.L without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.