Coix lacryma (Grenn Jôb) : medicinal properties in alcoholic extraction

Coix lacryma (Grenn Jôb) — family Poacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 24 indications in alcoholic extraction for this species. The monograph draws on 116 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Seed. Mentioned synergistic association: SORENAFIB.
   According to Yeh W (2021): In addition, the NB group had lower liver weight & hepatic triglyceride & cholesterol concentrations than did the NN group. Compared with the NN group, the high-dose NB group had improved steatosis, lower hepatic TNF-α, IL-1β & IL-6 levels, && lower adipose leptin levels. According to LI H (2024): Numerous pharmacological effects of Coix seed have been demonstrated through modern pharmacological studies, such as hypoglycemia, improving liver function, anti-tumor, regulating intestinal microbiota, improving spleen function, & anti-inflammatory effects.
2. Neurodegenerative disorders (taupathies) : Plant part used: Fruit Skin.
   According to Tsay GJ (2021): These extracts & its bioactive compound K36-21 may be potentially useful to treat neurodegenerative disorders. Alzheimer's disease (AD) is characterized by accumulation of β-amyloid (Aβ) in senile plaques, contributing to oxidative stress, mitochondrial diseases, & synaptic atrophy, consequently leading to the deterioration of brain function. According to Zhang CF (2019): Objective: This study evaluates the ameliorative effects of adlay seed extract (ASE) in a complete Freund's adjuvant (CFA)-induced rheumatoid arthritis (RA) rats.
3. High blood pressure, fluid retention, oedema : Plant part used: Seed. Documented pharmacological profile: Captopril-like.
   According to Li B (n.d.): Single oral administration of synthesized GAAGGAF at 15 mg/kg body weight (BW) in spontaneously hypertensive rats (SHR) could reduce the systolic blood pressure (SBP) around 27.50 mmHg & the effect lasted for at least 8 h. The study demonstrated for the first time that the ACE inhibitory peptide GAAGGAF from Coixglutelin has a significant antihypertensive effect, & it could be a good natural ingredient for pharmaceuticals against hypertension & the related diseases. According to SUI Y (2024): LPS-induced inflammation in RAW264.7 cells was well inhibited by compounds.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Agnieszka Kwiecień, Nova without modification (CC BY-SA 3.0). License : CC BY-SA 3.0.