Curcuma zedoria (Zédwè) : medicinal properties in alcoholic extraction

Curcuma zedoria (Zédwè) — family Zingiberacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The monograph draws on 112 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Hypercholesterolaemia, triglycerides, atherosclerosis : Plant part used: Rhizome. Documented pharmacological profile: Simvastatine-like. Mentioned synergistic association: Guazuma ulmifolia-feuille en décoction.
   According to Yasni S (n.d.): Thus, alpha-curcumene is one of the active principles exerting triglyceride-lowering activity in CX. xanthorrhiza in lipid metabolism, the hypotriglyceridaemic activity & the active principles of the EO & hexane-soluble fractions prepared from C. According to Yasni S (1991): xanthorrhiza decreased the concentrations of serum triglycerides and phospholipids, and liver cholesterol, and increased serum HDL-cholesterol and apo A-I.
2. Arthritis, osteoarthritis, rheumatism : Plant part used: Rhizome. Documented pharmacological profile: Diclofenac-like.
   According to Anggraeni W (2022): The results showed that the ethanol extract of CZ at doses of 300, 600, & 900 mg/kg bw had anti-inflammatory activity by decreasing the percentage of inflammation & increasing the percentage of inflammation inhibition. CONCLUSION: It can be concluded that CZ ethanol extract has anti-inflammatory & antioxidant activity. According to Yoshioka T (1998): Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene.
3. Pain, hyperalgesia (central and peripheral) : Plant part used: Rhizome. Documented pharmacological profile: Aspirine-like.
   According to Devaraj S (2010): These experimental results suggest that the standardized CX ethanolic extract showed peripheral & central antinociceptive activity associated with neurogenic pain as well as a relative absence of toxic effects which could compromise the medicinal use of this plant in folk medicine. The Analgesic activity was studied in rats using three different models, namely the hot plate test, tail flick test and formalin-induced pain test. According to Navarro D de F (2002): The results showed that the hydroalcoholic extract, fractions, especially dichloromethane, & a pure compound, denoted as curcumenol (1), exhibited potent & dose-related analgesic activity when evaluated in several models of pain in mice, including writhing, formalin and capsaicin.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by David J. Stang without modification (CC BY 4.0). License : CC BY 4.0.