Diospyros kaki (Persimmon) : medicinal properties in alcoholic extraction

Diospyros kaki (Persimmon) — family Ebénacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The monograph draws on 82 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Sheet. Documented pharmacological profile: Quercétine-like, Rutine-like.
   According to Hong C (2023): Experiments have shown that flavonoids or the extracts from the leaves of DK have a variety of good pharmacological activities, which could activate oxidative stress & mitochondrial apoptosis, inhibit the proliferation of human prostate cancer cells & induce apoptosis. It also could achieve the effect of anti-cancer cell proliferation & induce apoptosis by regulating oxidative stress. According to Forouzanfar F (2024): In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated.
2. Rheumatoid arthritis : Plant part used: Fruit. Documented pharmacological profile: Indometacine-like.
   According to Direito R (2020): The aim of this work was to evaluate the anti-inflammatory activity of a DK extract in rats with collagen-induced arthritis (CIA). The persimmon extract showed an anti-inflammatory effect given the significant reduction in both the edema volume & radiological alterations attributed to CIA in the bone. According to Ngem S (2024): It can be recommended that the necessity consumption of persimmon fruit juice in the diets of peoples exposed to rheumatoid arthritis, because of their anti-rheumatoid arthritis & antioxidants properties, and that play important role of health status.
3. Oxidative stress : Plant part used: Fruit. Documented pharmacological profile: Acide Ascorbique-like.
   According to Kim L (2017): The aim of this study was to investigate the protective effects of ethanol (EAP) and acidic ethanol extracts (AEAP) of astringent Persimmon fruits (Diospyros kaki) against hydrogen peroxide (H2O2)-induced oxidative stress in Caco-2 epithelial cells. Treatment with H2O2 induced oxidative stress in Caco-2 cells but had no effect on SOD activity. According to Shin EJ (2021): In addition, EED ameliorated impaired cholinergic system, increased oxidative stress as well as mitochondrial dysfunction compared with HFD group.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Vinayaraj without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.