Garcinia mangostana (Mangosteen) : medicinal properties in alcoholic extraction

Garcinia mangostana (Mangosteen) — family Clusiacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The monograph draws on 163 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infections : Plant part used: Fruit (pericarp).
   Selon GEETHA R (s.d.) : coli [GNB], Klebsiella pneumoniae [GNB], Vibrio cholerae [GNB], Pseudomonas aeruginosa [GNB] & Staphylococcus aureus, [Gram positive Cocci] using agar well diffusion technique. Antibacterial activity of ethanolic & aqueous fruit rind extract of GM was screened against Salmonella typhi, [Gram negative bacilli-GNB], Shigella dysenteriae [GNB], E. Selon Cunha BL (2014) : Evaluation by antimicrobial activity against Staphylococcus aureus & Escherichia coli by agar diffusion test and by determination of Minimum Inhibitory Concentration (MIC).
2. Cancer : Plant part used: Fruit (pericarp). Documented pharmacological profile: Bortezomib-like.
   Selon Fukuda M (2017) : The present study examined the impact of α-mangostin on human oral squamous cell carcinoma (HOSCC). However, it remains unclear whether α-mangostin induces cell death in oral cancer. Selon WANG JJ (2012) : This study examined the anti-skin cancer properties of crude ethanol extract of mangosteen pericarp (MPEE) on human squamous cell carcinoma A-431 and melanoma SK-MEL-28 lines.
3. Teratogenesis caused by retinoic acid : Plant part used: Fruit (pericarp). Documented pharmacological profile: Accutane-like.
   Selon Auteur (2017) : Mangosteen crude extract, extracted using 95% ETOH has higher yield of altering malformations caused by retinoic acid than mangosteen crude extract, extracted using 50% ETOH. On the contrary, both extracts administered with retinoic acid showed Antiteratogenic properties by minimizing the malformations on the duck embryo’s head width, eye diameter, culmen length, culmen depth, radius & ulna length, wing length, body length, total body length, shank length & foot length.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo from the Traditional Martinique Pharmacopoeia.