Lagenaria siceraria (Goud Sèpan) : medicinal properties in alcoholic extraction

Lagenaria siceraria (Goud Sèpan) — family Cucurbitacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The monograph draws on 107 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Sheet.
   Selon Prajapati RP (2010) : Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, & antibacterial effects so that its potential uses in pharmaceutics can be better evaluated. Boiled in oil this pulp is used to treat rheumatism & insomnia. Selon Deshmukh DB (2019) : Ethanolic extract of the fruit & leaves of Lagenaria siceraria was investigated in rats & mice for analgesic & anti-inflammatory activities.
2. Hepatotoxicity : Plant part used: Fruit. Documented pharmacological profile: Silymarine-like.
   Selon Panchal CV (2013) : Antioxidants are well known for their hepatoprotective effect & in curing liver disorders. Hepatoprotective activity was evaluated at three oral dose levels of 250, 500 & 1000 mg/kg. Selon Owais F (2019) : CONCLUSION: Hepatoprotective potential of L.S suggested its use to prevent elevation of hepatic enzymes due to long term administration of carbamazepine.
3. Obesity : Plant part used: Fruit. Documented pharmacological profile: Orlistat-like. Mentioned synergistic association: association synergique avec PIPER NIGRUM-L (Fruit), Terminalia arjuna-écorce.
   Selon Pallavi RD (2015) : There was a significant reduction in food intake, body weight, organ weights, TC, TG, LDL, locomotor activity & an increase in HDL levels in high fat diet fed rats treated formulation containing Lsiceraria, T arjuna & P longum as compared to the Positive Standard, Marketed & Normal treated animals. In the present study, new anti-obesity polyherbal formulations were developed & their effect was studied in female rats fed on high fat diet. Selon Vaibhav A (2016) : Conclusion: LS fruit juice effectively controls obesity & overweight.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Hyunjung Kim without modification (CC BY 4.0). License : CC BY 4.0.