Mucuna pruriens (Scratch-and-win) : medicinal properties in alcoholic extraction

Mucuna pruriens (Scratch-and-win) — family Fabacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 134 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Seed. Documented pharmacological profile: Cisplatine-like.
   Selon Kumar P (2016) : The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). M1 was active against Huh-7 cells that may be useful for future hepatic cancer treatment,. Selon RAJESHWAR Y (2005) : The results suggest that the methanol extract of MP seeds exhibits significant antitumor & antioxidant effects in EAC bearing mice,.
2. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Metformine-like.
   Selon Reuben-Kalu IJ (2021) : Oral administration of ASEMP against the nicotinamide-streptozotocin-induced diabetes in the Wistar rats showed anti-hyperglycemic effect on the blood glucose level (94 ± 0.2 mg/dl ASEMP 400 mg/kg) when compared with the control group (92 ± 0.2 mg/dl Glibenclamide 5 mg/kg), (248 ± 0.3 mg/dl Diabetic control) & (90 ± 0.3 mg/dl Normal control). Significant reduction in creatinine level of the nicotinamide-streptozotocin-induced diabetic rats treated with ASEMP was also recorded. Selon Murugan M (2009) : The chloroform fraction was screened for its hypoglycemic & hypolipidemic activity, the result was comparable with the positive control Glibenclamide.
3. Liver disorders : Plant part used: Sheet. Documented pharmacological profile: Silymarine-like.
   Selon GENEVIA FATIMA MERCY V (2025) : Conclusion: MP derived Zn NPs exhibit potent biological activities, highlighting their potential as a natural therapeutic strategy for managing oxidative stress & inflammatory diseases. Results: The MP derived Zn NPs demonstrated significant antioxidant, anti-inflammatory, & anti-arthritic activities. Selon Obogwu MB (2014) : This study investigated the hepatoprotective & in vivo antioxidant activities of the hydroethanolic extract of Mucuna pruriens leaves in antitubercular & alcohol-induced hepatotoxicity assays in rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Scott Zona without modification (CC BY 2.0). License : CC BY 2.0.