Nepheleum lappaceum (Rambutan) : medicinal properties in alcoholic extraction

Nepheleum lappaceum (Rambutan) — family Sapindacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 109 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Gentamycine-like.
   Selon Bhat RS (s.d.) : Both seed aqueous extracts show moderate inhibition against pathogenic bacteria, both gram positive including Staphylococcus aureus, Streptococcus pyogenes, & Bacillus subtilis & gram-negative bacteria including Escherichia coli & Pseudomonas aeruginosa. Seeds aqueous extracts from Litchi chinensis & Nephelium lappaceum were investigated for antibacterial activity by disc diffusion method & protein profile. Selon Rajasekaran, A (2013) : lappaceum) were investigated for anti-nociceptive, CNS, antibacterial & antifungal activities.
2. Hypercholesterolaemia : Plant part used: Fruit peel. Documented pharmacological profile: Cholestyramine-like.
   Selon Susilawati R (2018) : It can be concluded that the NL seed extract at the dose of 19.2 mg/kgbw had the potential to reduce the risk of cardiovascular diabetes in mice by increasing lipid fraction & decreasing oxidative stress. The result indicated that 70% ethanol extract of NL seeds had a significant effect on the atherosclerosis index (p <0,01) & all lipid profile parameters. Selon Suhendi A (2015) : While the antihypercholesterolemia activity of the ethanol extract of NL peel with dose of 125, 250, & 500 mg/kgBW had an activity to lower cholesterol levels 21.39 ± 6.61%, 31.15 ± 18.15%, & 60.75 ± 8.26%, respectively.
3. Dyslipidaemia : Plant part used: Sheet. Documented pharmacological profile: Simvastatine-like.
   Selon Suhendi A (2015) : While the antihypercholesterolemia activity of the ethanol extract of NL peel with dose of 125, 250, & 500 mg/kgBW had an activity to lower cholesterol levels 21.39 ± 6.61%, 31.15 ± 18.15%, & 60.75 ± 8.26%, respectively. The results showed that the ethanol extract of NL fruit peel with dose of 125, 250, & 500 mg/kgBW had blood glucose lowering activity in mice induced alloxan, the percentage decrease in blood glucose levels at 22.65 ± 2.10%, 49.05 ± 3.22%, 61.76 ± 4.26%. Selon Ma Q (2017) : RPP significantly reduced the serum levels of total cholesterol, triglyceride, creatinine, & glycated serum protein in diabetic mice in a dose-dependent manner.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Dmitry Brant without modification (CC BY 4.0). License : CC BY 4.0.