Origanum majorana (Marjoram) : medicinal properties in alcoholic extraction

Origanum majorana (Marjoram) — family Lamiacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 27 indications in alcoholic extraction for this species. The monograph draws on 86 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Gout, urinary stones : Plant part used: Flower. Documented pharmacological profile: Allopurinol-like.
2. Oxidative stress : Plant part used: Aerial parts. Documented pharmacological profile: BHT-like.
   Selon Ramadan G (2013) : The present study showed (probably for the first time) that both MLP and MLE (especially the high dose) significantly alleviated (P < 0.05-0.001) erythrocytosis, agranulocytosis, thrombocytosis, shortened clotting time, the increase in relative heart weight, myocardial oxidative stress & the leakage of heart enzymes (creatine phosphokinase (CPK), CPK-MB isoenzyme, lactate dehydrogenase & aminotransferase) in ISO-treated rats through reactivating non-enzymic (reduced glutathione) and enzymic (catalase, glutathione peroxidase, glutathione S-transferase, superoxide dismutase) antioxidant defence system & inhibiting the production of nitric oxide & lipid peroxidation in heart tissues. Selon Moghaddam M G (2013) : Moghaddam M G et al, The Effects of Origanum Majorana on Oxidative Stress & Histopathology of Renal Tissue among Streptozotocin-Induced Diabetic Rats, Thrita.
3. Cancer : Plant part used: Sheet.
   Selon Al Dhaheri Y (2013) : In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative & invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. majorana may be a promising chemopreventive & therapeutic candidate against cancer especially for highly invasive triple negative p53 mutant breast cancer; thus, validating its complementary & alternative medicinal use,. Selon Al-Dhaheri Y (s.d.) : Al-Dhaheri Y et al, Antimetastatic & Antitumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling & Reduction of Nitric Oxide Production, PLoS ONE 8(7): e68808.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

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