Parkinsonia aculeata (Jerusalem thorn) : medicinal properties in alcoholic extraction

Parkinsonia aculeata (Jerusalem thorn) — family Caesalpiniacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The monograph draws on 35 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Aerial parts. Documented pharmacological profile: Cisplatine-like.
   Selon Hassan S (2008) : Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Hepatoprotective activity was measured based on biochemical parameters. Selon Rani P (2018) : Methods: Anticancer activity of PA (EEPA) of leaf extract was evaluated in Swiss albino mice against Ehrlich ascites carcinoma (EAC) cell line at the doses of 200 & 400 mg/kg body weight orally.
2. Dyslipidaemia : Plant part used: Aerial parts. Documented pharmacological profile: Gemfibrozil-like.
   Selon Franco ES (2022) : Treatment with PfrHEPA (140 mg/kg), even with the continued consumption of westernized diet by animals (from 120 to 150 days) promoted a significant reduction in total cholesterol, LDL & triglyceride levels, in relation to untreated W group. The objective of this study was to evaluate the effects of polar fraction obtained from the hydroethanolic extract of PA(PfrHEPA) on the lipid profile of animals that consumed a westernized diet. Selon Rani P (2018) : The extracts significantly (p<0.05) decreased the levels of lipid peroxidation & significantly (p<0.05) increased the levels of reduced glutathione, superoxide dismutase & catalase.
3. Type II diabetes mellitus : Plant part used: Aerial parts. Documented pharmacological profile: Insuline-like, Metformine-like.
   Selon Leite ACR (2011) : This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal & alloxan-induced diabetic rats, treated with HEPA (125 & 250 mg/kg; p.o.). aculeata presents an antidiabetic activity & other beneficial effects that ameliorate diabetes & associated complications. Selon Leite ACR (2007) : Leite ACR et al, Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by SAplants without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.