Polygala paniculata (Lèsta-frajil) : medicinal properties in alcoholic extraction

Polygala paniculata (Lèsta-frajil) — family Polygalacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The monograph draws on 15 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Anxiety, depression, nervousness, psychosis, schizophrenia : Plant part used: Sheet. Documented pharmacological profile: Sulpiride-like.
   Selon LE Bettio (2011) : Pretreatment of mice with yohimbine (1 mg/kg, i.p., α₂-adrenoceptor antagonist), propranolol (1 mg/kg, i.p., β-adrenoceptor antagonist), SCH23390 (0.05 mg/kg, S.C., dopamine D₁ receptor antagonist) or Sulpiride (50 mg/kg, i.p., dopamine D₂ receptor antagonist) prevented the antidepressant-like effect of the extract in FST (30 mg/kg). The antidepressant-like effect of the hydroalcoholic extract from P.
2. Pain, oedema : Plant part used: Sheet.
   Selon NOGUEIRA FLP (2005) : The ethanolic extracts obtained from Wild and micropropagated plants produced Analgesic effects against thermal and chemical induced pain. (Polyggalaceae), which is a herbaceous plant widely distributed all over Brazil, were tested for their Analgesic effects using hot plate, tail flick and formalin test models, and for their antiedematogenic effects using croton oil induced ear oedema. Selon Wang H (2008) : Wang H et al, Anti-inflammatory activities of triterpenoid saponins from Polygala japonica.
3. Candidiasis : Plant part used: Pest Control and Veterinary Products.
   Selon Johann S (2011) : tropicalis (250 μg/mL) and S. paniculata showed antifungal activity against C.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo from the Traditional Martinique Pharmacopoeia.