Polyscias fructicosa (Gwo Womaren) : medicinal properties in alcoholic extraction

Polyscias fructicosa (Gwo Womaren) — family Araliacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The monograph draws on 66 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bronchial asthma : Plant part used: Sheet. Documented pharmacological profile: Ketotifène-like, Cromoglycate-like.
   (2016) : Conclusion: PFE has anti-asthmatic, antihistaminic, & mast cell stabilization effect making it useful in traditional asthma management. PFE significantly inhibited (60.4 ± 8.3%) contractile responses of histamine & produced significant inhibition (56-79%: p ≤ 0.001) of mast cell degranulation. Selon Koffuor GA (2014) : PFE showed no significant toxic effect at lower doses (NOAEL: < 1000 mg/kg) Conclusion: The ETOH leaf extract of PF reduces white blood cell count & its differentials in blood, hence its anti-inflammatory effect; a useful property in the treatment of asthma.
2. Osteoarthritis, rheumatism, oedema, arthritis : Plant part used: Sheet. Documented pharmacological profile: Phenylbutazone-like.
   Selon Rarison R.H.G (2023) : Additionally, lipophilic fractions from PFL showed anti-inflammatory potential in downregulating the level of pro-inflammatory factors in LPS-treated macrophages. This study, integrating network pharmacology analysis with in silico & in vitro approaches, aimed to elucidate the antioxidant & anti-inflammatory capacities of lipophilic extracts from PFL. Selon Bernard BM (1998) : The n-butanol extract of the leaves Polyscias fruticosa (L) Harms (Araliaceae) was tested for its anti-inflammatory activity plethysmometrically in egg white induced paw oedema in rats, antipyretic activity & analgesic activity by writhing method phenylbutazone, paracetamol & aspirin were used as positive controls for anti-inflammatory, antipyretic & analgesic activity screening studies receptivity.
3. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Amoxicilline-like.
   Selon Titova, M.V (2023) : In antibacterial tests, the minimum inhibitory concentrations (MICs) of cell biomass extracts against the most common pathogens Staphylococcus aureus, Methicillin-Resistant strain MRSA, Pseudomonas aeruginosa, & Escherichia coli varied within 250-2000 µg mL-1 which was higher compared to extracts of greenhouse plant leaves (MIC = 4000 µg mL-1). Polyscias fruticosa (L.) Harms, or Ming aralia, is a medicinal plant of the Araliaceae family, which is highly valued for its antitoxic, anti-inflammatory, analgesic, antibacterial, anti-asthmatic, adaptogenic, & other properties. Selon Ashmawy (2020) : Phytochemical investigations of Polyscias species revealed the isolation of about 97 chemical compounds from various chemical classes, including saponins as major constituents; Biological studies demonstrated that Polyscias extracts & their bioactive compounds possess antibacterial, antifungal, cytotoxic, immuno-stimulant, wound-healing & anti-asthmatic activities;.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo de Mauricio Mercadante sans modification. License : CC BY-NC-SA 2.0.