Rhodiola rosea (Rhodiola) : medicinal properties in alcoholic extraction

Rhodiola rosea (Rhodiola) — family Crassulacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The monograph draws on 203 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Dystonia, rigidity, bradykinesia : Plant part used: Rhizome. Documented pharmacological profile: Benzatropine (Cogentin*)-like.
2. Cancer : Plant part used: Rhizome. Documented pharmacological profile: Cyclophosphamide-like.
   Selon ZHANG X (2020) : Methods: The effects of RR on NSCLC were examined in Lewis lung carcinoma (LLC) tumor-bearing mice models. Lung cancer is the most common and mortal cancer worldwide. Selon ZHANG Y (2019) : Methods: Lewis’s lung cancer-bearing mice were randomly divided into normal saline group, 500 mg/kg RRL ethanol extract treatment group, & 10 mg/kg cyclophosphamide (CTX) treatment group.
3. Oxidative stress : Plant part used: Rhizome. Documented pharmacological profile: Acide ascorbique-like.
   Selon KIM KJ (2021) : RR rhizome & its identified compounds protected neuronal PC-12 cells against oxidative stress & showed moderate acetylcholinesterase inhibition. We aimed to authenticate RR rhizome using the DNA barcoding technique & to quantify its main compounds, total phenolics, total flavonoids, & antioxidant capacity, & then to investigate their neuroprotective effects. Selon BABAVI SF (2016) : A plethora of studies report that RR has potent neuroprotective effects through the suppression of oxidative stress, neuroinflammation, & excitotoxicity in brain tissues & antagonism of oncogenic p21-activated kinase.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Alpsdake without modification. License : CC BY-SA 4.0.