Ricinus communis (Fèy-grenn’) : medicinal properties in alcoholic extraction

Ricinus communis (Fèy-grenn’) — family Euphorbiacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The monograph draws on 42 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Sheet. Documented pharmacological profile: Paclitaxel-like.
   Selon Majumder M (2019) : RCFE (0.5 mg/Kg body weight) treatment led to significant reduction in tumor volume in 4T1 syngeneic mouse model. Here, we report the anti-cancer efficacy of Ricinus communis fruit extract (RCFE) using estrogen positive MCF-7 & highly aggressive, triple negative MDA-MB-231 breast cancer cells. Selon Soto KM (2069) : communis) leaves (AuNPsCE) ethanolic extracts in human HT29 & SW480 colorectal cancer cells.
2. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Glibenclamide-like.
   Selon Gad-Elkareem M (2019) : This study aimed to investigate the antidiabetic effect of ethanolic & aqueous-ethanolic extracts of wild Ricinus communis leaves in streptozotocin (STZ) induced diabetic rats. A significant increase in the AST, ALT & ALP levels (P < 0.05) was observed in the diabetic control & in the experimental groups with Glibenclamide which was also significantly (P < 0.05) lowered after treatment with extracts at special doses. Selon Shokeen P (2008) : We investigated the antidiabetic activity of 50% ethanolic extract of roots of Ricinus communis (RCRE) along with its Bioassay-guided purification.
3. Rheumatoid arthritis : Plant part used: Sheet. Documented pharmacological profile: Méthotrexate-like.
   Selon Hussain A (2021) : This study aimed to evaluate the anti-arthritic activity of Ricinus communis leaves' & Withania somnifera roots' hydroalcoholic extracts in Complete Freund's adjuvant-induced arthritis in Wistar rats. Changes in paw swelling, arthritic score, body weight, organ indices (thymus & spleen), hematological & biochemical parameters, & pro-/anti-inflammatory cytokine expression using qRT-PCR were assessed. Selon Nemudzivhadi V (2014) : Cytotoxic effect & anti-inflammatory activity of RC leaves extracts were evaluated on Human Caucasian skin fibroblast & Raw 264.7 macrophage cell lines, respectively.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Vijayanrajapuram without modification (CC BY 4.0). License : CC BY 4.0.