Stevia rebaudania (stevia) : medicinal properties in alcoholic extraction

Stevia rebaudania (stevia) — family Asteracées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The monograph draws on 190 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Sheet. Documented pharmacological profile: 5-Fluoro-Uracile-like.
   Selon Rajesh P (2010) : Anticancer activity of ethanolic extract of leaves of Stevia Rebaudiana was determined in the rat by induced Ehrlich’s Ascites carcinoma. At doses of 100 & 300 mg/kg/i.p., the extract inhibited proliferation of cell count significantly (P<0.01) compared with 5-Fluoro Uracil (20 mg/kg/i. Selon Iatridis N (2040) : Consequently, our main objective was to present a concise, literature-based review of the biological actions of stevia derivatives in various tumor types, as studied in in vitro & in vivo models of the disease.
2. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Glibenclamide-like. Mentioned synergistic association: Andrographis paniculata-feuille.
   Selon KHAKPAI F (2023) : Type II diabetes mellitus is a group of metabolic disorders considered chronic hyperglycemia resulting from deficits in insulin secretion or insulin function. Therefore, induction of diabetes in rats produced hyperglycemia, anxiogenic effect, & memory impairment & these responses were reversed by drug treatment. Selon PETRUS RISKY P (2017) : This study was conducted to determine the optimal effectiveness of ethanol extract combination of stevia leaves & bitter leaves of oxidative stress in diabetic Mellitus rats compared in single form.
3. Periodontitis, dental plaque, tooth decay : Plant part used: Sheet. Documented pharmacological profile: Chlorhexidine-like.
   Selon Ajagannanavar SL (2014) : rebaudiana extract against Streptococcus mutans & Lactobacillus acidophilus in comparison to chlorhexidine. Mean zone of inhibition of the chlorhexidine against S mutans & L acidophilus at 48 hours was 20.5 & 13.2 respectively. Selon Lemus-Mondaca R (2012) : Stevia extracts, besides having therapeutic properties, contain a high level of sweetening compounds, known as steviol glycosides, which are thought to possess antioxidant, antimicrobial & antifungal activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Forest & Kim Starr without modification (CC BY-SA 3.0). License : CC BY-SA 3.0.