Synsepalum dulcificum (Miracle fruit) : medicinal properties in alcoholic extraction

Synsepalum dulcificum (Miracle fruit) — family Sapotacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The monograph draws on 53 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Shaft.
   Selon Swamy KB (2013) : This effect was shown to be related to a glycoprotein called "miraculin." Other beneficial characteristics of this fruit were its antioxidant & anticancer abilities that are due to the various amides existing in the miracle fruit. Selon LU S (2014) : In addition, the antitumoral activity using MTT assay of the leaf essential oil exhibited this oil was effective against human K562 cancer cell line in a dose dependent manner.
2. Type II diabetes mellitus : Plant part used: Fruit. Documented pharmacological profile: Metformine-like.
   Selon Dioso MK (2016) : The Hypoglycemic effects of its fruit & leaf extracts on the blood glucose level of alloxan-induced diabetic albino rats were determined & compared with the positive control using Metformin. Twenty-five albino rats were induced with type 2 diabetes mellitus using alloxan and were grouped and treated into five treatments (positive control using metformin, 50% fruit extract, 50% leaf extract, 100% fruit extract, 100% leaf extract).Blood glucose level were analyzed and compared. Selon Obafemi TO (2017) : Obafemi TO et al, Antidiabetic potential of methanolic & flavonoid-rich leaf extracts of Synsepalum dulcificum in type 2 diabetic rats, J of Ayurveda & Integrative Med, 8(4):238-26, 2017,.
3. Hypercholesterolaemia, hyperlipidaemia, hypertriglyceridaemia : Plant part used: Sheet.
   Selon Auteur (s.d.) : Practical applications In recent years, people are more interested in phytochemicals from functional foods treated for hyperlipidemia because they possessed fewer side effects than the synthetic drugs.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Scott Zona without modification (CC BY-SA 2.0). License : CC BY-SA 2.0.