Ocimum basilicum (Basil) : medicinal properties in alcoholic extraction

Ocimum basilicum (Basil) — family Lamiacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 26 indications in alcoholic extraction for this species. The monograph draws on 119 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Sheet. Documented pharmacological profile: Cisplatine-like.
   Selon MANOSROI J (2006) : Anti-proliferative activity of essential oil from 17 Thaï medicinal plants on human mouth epidermal carcinoma (KB) & murine leukemia (P388) cell lines using MTT assay were investigated. In KB cell line, Guava (Psidium guajava L.) leaf oil showed the highest anti-proliferative activity with the IC50 value of 0.0379 mg/ml (4.37 times more potent than vincristine) whereas Sweet Basil (Ocimum basilicum L.) oil gave the highest antiproliferative activity with the IC50 value of 0.0362 mg/ml (12.7 times less potent than 5-FU) in P388 cell line. Selon Alkhateeb MA (2021) : Human MCF7 breast cancer cells were then treated with 3 separate fluctuated concentrations of 0, 50, 150 & 250 µg/mL for 24 and 48 h.
2. Bacterial and fungal infection : Plant part used: Sheet. Documented pharmacological profile: Itraconazole-like. Mentioned synergistic association: lagenaria siceraria-hile fixe.
   Selon El-Samahy LA (2024) : OB-LNPs & LS-LNPs were tested for their antimicrobial potential against Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella enterica, Trichophyton mentagrophytes, Trichophyton rubrum, & Microsporum canis. rubrum infection in a guinea pig model. Selon -Patil DD (2011) : -Patil DD et al, Antibacterial & Antioxidant study of Ocimum basilicum Labiatae (sweet basil), J of Adv Pharm Educ & Res, 2: 104-112 (2011),.
3. Mosquito control : Plant part used: Pest control & veterinary. Documented pharmacological profile: Temephos-like.
   Selon Hiba El-Amin M (1905) : The present study is designed to investigate the potentialities of Ocimum basilicum leaves powder (LP) & leaf powder –ethanolic extract (LPE) as a larvicide of Anopheles arabiensis 3rd instar larvae (L3) & comparing their results with those of the commonly used (OP) organophosphates larvicide Temephos. A cross sectional study was conducted in Barakat area to collect the Anopheles larvae, identified at the first stage as Anopheles arabiensis & the third stage. Selon Adam AA (2019) : In this work, the EO was assessed for topical repellence effects against malarial vector Anopheles mosquito in cages.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Mokkie without modification (CC BY 4.0). License : CC BY 4.0.