Phyllanthus niruri (Grenn ’-anba-fèy) : medicinal properties in alcoholic extraction

Phyllanthus niruri (Grenn ’-anba-fèy) — family Phyllantacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The monograph draws on 148 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Whole plant. Documented pharmacological profile: Streptomycine-like.
   Selon Ferrante C (2020) : In this context, the aim of the present study was to explore the efficacy of extracts from Solidago virga-aurea, Ononis spinosa, Peumus boldus, Epilobium angustifolium, & Phyllanthus niruri against bacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus) and fungi strains (Candida albicans; C. The phytochemical analysis highlighted that rutin levels could be crucial for explaining the highest antibacterial activity of P. Selon Shoeb M (2022) : niruri was tested against two Gram negative (Escherichia coli, Salmonella typhi) & two Gram positive (Bacillus subtilis & Staphylococcus aureus) bacteria following agar diffusion method.
2. Cancer : Plant part used: Whole plant. Documented pharmacological profile: Paclitaxel-like.
   Selon Jia L (2013) : The aim of the present study is to investigate the anticancer properties of Corilagin in ovarian cancer cells. Corilagin induced cell cycle arrest at the G2/M stage & enhanced apoptosis in ovarian cancer cells. Selon Raja W (2019) : The results thus suggest that PN extract exhibits significant anti-tumor activity, which supports the traditional medicinal utilization of this plant.
3. Type II diabetes mellitus : Plant part used: Aerial parts. Documented pharmacological profile: Metformine-like.
   Selon Okoli CO (2010) : The antidiabetic potentials of methanol extract (ME) of aerial parts of Phyllanthus niruri L (Euphorbiaceae) was evaluated in normal and alloxan diabetic rats. Results suggest that extract of aerial parts of PN has great potentials as anti-diabetic remedy,. Selon Giribabu N (2014) : Aqueous extract of Phyllanthus niruri leaves displays in vitro antioxidant activity & prevents the elevation of oxidative stress in the kidney of streptozotocin- induced diabetic male rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Pisofrix without modification (CC BY 4.0). License : CC BY 4.0.