Piper nigrum (Pwèv-nwè) : medicinal properties in alcoholic extraction

Piper nigrum (Pwèv-nwè) — family Piperacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 25 indications in alcoholic extraction for this species. The monograph draws on 93 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: streptomycine-like.
   Selon Manjukeswari S (2013) : The present study aimed at evaluating the antibacterial activity of ethanolic extracts of leaves of Piper nigrum, Piper longum & Adhatoda vasica against Streptococcus mutans, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae. The results revealed that the ethanolic extract of leaf presented the highest zone of inhibition in B subtilis, S mutans. Selon Ertuk O (2011) : Eleven ethanolic extracts from spices of Melissa officinalis(FR:FE), Mentha piperita((Se), Laurus nobilis(Fe), Rhus coriaria, Dianthus coryophyllum, Piper nigrum(Se), Capsicum annum (Fr), Juniperus oxycedrus, Erica arborea, Colutea arborescens, & Cuminum cyminum(Fr) collected from various regions of Turkey & local markets were assayed for the in vitro antibacterial activity against 3 Gram-positive (Bacillus subtilis, Staphylococcus aureus & S.
2. Adjuvant treatment for Alzheimer’s disease : Plant part used: Fruit. Documented pharmacological profile: Donepezil-like. Mentioned synergistic association: Myristica fragans, Syzygium aromaticum.
   Selon Cheng C (2020) : On the basis of the activities of its individual components, KBD could have good potential for the treatment of Alzheimer's disease (AD). Selon Pratibha N (2004) : Aller-7 also exhibited a dose-dependent (150-350 mg/kg) anti-inflammatory effect against Freund's adjuvant-induced arthritis in Wistar Albino rats & an approximately 63% inhibitory effect was observed at a dose of 350 mg/kg. The efficacy of Aller-7 was investigated in compound 48/80-induced paw edema both in Balb/c mice & Swiss Albino mice, carrageenan-induced paw edema in Wistar Albino rats & Freund's adjuvant-induced arthritis in Wistar Albino rats.
3. Cancer : Plant part used: Fruit. Documented pharmacological profile: Méthotrexate-like.
   Selon Turrini E (2020) : The main limits of current anticancer therapy are relapses, chemoresistance, & toxic effects resulting from its poor selectivity towards cancer cells that severely impair a patient's quality of life. The present review aims to provide a comprehensive overview of the anticancer potential of PN & its major active constituents-not limited to the well-known piperine-whose undeniable anticancer properties have been reported for different cancer cell lines & animal models. Selon Pratibha N (2004) : These results demonstrate that this novel polyherbal formulation is a potent anti-inflammatory agent that can ameliorate the symptoms of allergic rhinitis.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by David J. Stang without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.