Pisonia aculeata (Kwôk-chien) : medicinal properties in alcoholic extraction

Pisonia aculeata (Kwôk-chien) — family Nyctaginacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The monograph draws on 24 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Glibenclamide-like.
   Selon Mamoon Hussain S (2013) : Methods: Ethylacetate & ethanolic extract of the leaves of P aculeata were administered orally at doses of 100mg/kg & 200 mg/kg in normal and alloxan- induced diabetic rats. The aim of the present study was to evaluate the antihyperglycemic effect of leaves of Pisonia aculeata (Family: Nyctaginaceae) on alloxan-induced diabetes in rats. Selon Teja T (2013) : Hyperlipidemia has been associated as a complication with several metabolic diseases, including diabetes mellitus.
2. Liver disease : Plant part used: Sheet. Documented pharmacological profile: Silymarine-like.
   Selon Anbarasu C (2011) : Methanolic extract of leaves of Pisonia aculeata (250 & 500 mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against Rifampicin & Isoniazid induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. Results indicate the hepatoprotective & antioxidant properties of P aculeata against rifampicin & isoniazid -induced hepatotoxicity in rats,. Selon Palanivel M (2008) : The plant extract (250 & 500 mg/kg, p.o.) showed a remarkable hepatoprotective a&antioxidant activity against carbon tetrachloride (CCl 4) -induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues.
3. Hypercholesterolaemia, hyperlipidaemia, hypertriglyceridaemia : Plant part used: Whole plant. Documented pharmacological profile: Lovastatine-like.
   Selon Teja T (2013) : Hyperlipidemia has been associated as a complication with several metabolic diseases, including diabetes mellitus. Anti hyperlipidemic activity mainly due to the modulation of cholesterol levels, LDL, HDL, cholesterol levels, through an improvement of HDL – cholesterol levels & partly to reduce the levels of triglycerides. Selon Chakraborthy R (2008) : Extracts induced a rise in Na+/K+-ATPase activity, & ameliorated level of different enzymatic and non-enzymatic antioxidants positively, whereas lipid peroxidation decreased significantly.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

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