Punica granatum (Grinad) : medicinal properties in alcoholic extraction

Punica granatum (Grinad) — family Punicacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 43 indications in alcoholic extraction for this species. The monograph draws on 220 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Seed. Mentioned synergistic association: Zizyphus mauritiana-semence.
   Selon NURUJJAMAN M (2024) : The anticancer activity of the lectin was examined using in vivo & in vitro functional assays. In vitro MTT assay showed that PgL inhibited Ehrlich ascites carcinoma (EAC) cell growth in a dose-dependent manner. Selon Wong TL (2021) : It discusses the chemical constituents of pomegranate, the results of both preclinical (in vitro, ex vivo & in vivo) & clinical studies on the anticancer effect of pomegranate phytochemicals & molecular targets in numerous types of cancers, such as breast, gastrointestinal tract (oral, colon, liver & pancreas), gynecological (uterine & ovarian), hematological (lymphoma, leukemia & myeloma), lung, neurological (glioma), urogenital (bladder & prostate), bioavailability, pharmacokinetics & safety of pomegranate constituents.
2. Viremia : Plant part used: Sheet. Documented pharmacological profile: Acyclovir-like.
   Selon Angamuthu D (2019) : Human Herpes Virus-3 (Varicella Zoster Virus) causes Chickenpox in childhood & reactivates after decades from its latency to cause Herpes Zoster. The present study is an in vitro antiviral investigation on the leaves of Punica granatum against the clinical isolates of Human Herpes Virus-3 in comparison with acyclovir. Selon Abdollahzadeh S (2011) : Antibacterial & antifungal activities of Punica granatum peel extracts against oral pathogens, Jl of Dentistry, 8 (1) :1–6, 2011.
3. Pain, hyperalgesia : Plant part used: Fruit pericarp. Documented pharmacological profile: Aspirine-like, Tramadol-like.
   Selon Ben Saad L (2014) : Materials & Methods: Antinociceptive activity of ethanol pomegranate extract was examined using three models of pain: the writhing test, the hot tail flick test & the plantar test. Results: In the writhing test, the index of pain inhibition (IPI) was 37% for ethanolic extract of pomegranate (200mg/kg, p.o), & 59% for aspirin. Selon RAAFAT K (s.d.) : Conclusion: Pg extract, F1, F2, & GA could be considered as a new therapeutic potential for the amelioration of diabetic neuropathic pain & the observed in vivo antioxidant potential may be involved in its antinociceptive effect.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by H. Zell without modification (CC BY 4.0). License : CC BY 4.0.