Ziziphus mauritiana (Jijib) : medicinal properties in alcoholic extraction

Ziziphus mauritiana (Jijib) — family Rhamnacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 24 indications in alcoholic extraction for this species. The monograph draws on 91 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Fruit. Documented pharmacological profile: Doxorubicine-like.
   Selon Hosmer R (2015) : jujube fruit on the proliferation of breast cancer cells by MTT assay and the antioxidant by FRAP, haematological & biochemical alterations caused by NMU(Methyl-Nitroso-Urea)-induced mammary carcinogenesis in rats. Conclusions: These findings indicate that the ZJ ameliorates the adverse effects of NMU carcinogenesis & could be useful for treating mammary tumours in humans. Selon Plastina P (2012) : Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative & apoptotic effects in human breast cancer cells.
2. Pain, hyperalgesia : Plant part used: Bark. Documented pharmacological profile: Diclofenac-like.
   Selon Rahman S (2012) : Antioxidant, analgesic, cytotoxic & antidiarrheal activities of the extract were investigated using 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay, acetic acid induced writhing inhibition, brine shrimp lethality bioassay & castor oil induced diarrhea inhibition respectively.
3. Malaria : Plant part used: Seed. Documented pharmacological profile: Chloroquine-like, Pyrimethamine-like.
   Selon Mishra T (2014) : The present study determines the antiplasmodial effect of aqueous ethanolic seed extract against Chloroquine sensitive Plasmodium berghei b. Although, the activity was lower than standard chloroquine. Selon TSILA Ss (2025) : The ethanol extract, along with its derived fractions, demonstrated potent in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7 (Pf3D7), with the ethyl acetate-soluble (IC50 = 11.35 µg/mL) and alkaloid-rich (IC50 = 4.75 µg/mL) fractions showing particularly strong inhibition.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Ethel Aardvark without modification (CC BY 3.0). License : CC BY 3.0.