Agaricus blazei (Agaric) : medicinal properties in alcoholic extraction

Agaricus blazei (Agaric) — family Agaricacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 118 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Viremia : Plant part used: Mycelium. Documented pharmacological profile: Acyclovir-like.
   According to Tramontani Gomes de Souza-Cardoso F (2011): MI-S also presented synergistic antiviral effect with acyclovir. Herein we report the chemical modification of a polysaccharide extracted from AB mycelia to obtain its sulfated derivative (MI-S), which presented a promising inhibitory activity against HSV-1 [KOS & 29R (acyclovir-resistant) strains] & HSV-2 strain 333, with selectivity indices (SI = CC50/IC50) higher than 439, 208, & 562, respectively. According to Stojković D (2014): The antioxidant and antimicrobial activities of methanolic & ethanolic extracts were assessed.
2. Bacterial infection : Plant part used: Mycelium.
   According to Guerra-Lund R (2009): Crude ethanol extracts (100% EtOH, 75% EtOH, & 50% EtOH, v/v) obtained from dried basidiomes of ABs were assessed against Streptococcus mutans UA159 & Streptococcus sobrinus 6715 by the agar diffusion method, determination of minimum inhibitory concentration (MIC) & minimum bactericidal concentration (MBC), & inhibition of cell adherence to a glass surface. mutans, but only the 75% ethanol extract was bactericidal against S. According to Stojković D (2014): The antioxidant and antimicrobial activities of methanolic & ethanolic extracts were assessed.
3. Liver disorders : Plant part used: Mycelium.
   According to Al-Dbass AM (2012): The findings indicate that the extract of AB can protect the liver against carbon tetrachloride induced oxidative damage in rats & is an efficient hepatoprotective & antioxidant agent against carbon tetrachloride induced liver injury. The present study investigated the protective effect of this biologically active mushroom on the tissue peroxidative damage & abnormal antioxidant levels in carbon tetrachloride induced hepatotoxicity in male albino rats. According to Barbisan L.F (2002): blazei exerts a hepatoprotective effect on both liver toxicity & hepatocarcinogenesis process induced by a moderately toxic dose of DEN.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Alan Rockefeller without modification (CC BY 4.0). License : CC BY 4.0.