Cardiospermum halicacabum (Bonè-karé) : medicinal properties in alcoholic extraction

Cardiospermum halicacabum (Bonè-karé) — family Sapindacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 70 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Osteoarthritis, arthritis, rheumatism : Plant part used: Whole plant. Documented pharmacological profile: Indometacine-like.
   According to Cheng HL (2013): Cheng HL et al, Antiinflammatory & Antioxidant Flavonoids & Phenols from Cardiospermum halicacabum, Jl of Trad &Comp Med, 3 (1) :33-40, 2013,. According to Kumar E (2008): In this study, the anti-arthritic effect of oral administration of ethanolic extract of Cardiospermum halicacabum leaves (CEE) at the dose of 125 mg/kg and 250 mg/kg on Freund’s complete adjuvant (FCA) induced arthritis has been studied in rats. The results suggest that the ethanolic extract of Cardiospermum halicacabum leaves exhibits significant anti-arthritic effect.
2. Anxiety, nervousness : Plant part used: Root. Documented pharmacological profile: Diazepam-like.
   According to Malaviya S (2009): These results suggest that alcoholic & aqueous extracts of CH possess anti-anxiety activity. Anti-anxiety activity was evaluated using elevated plus maze (EPM), light dark model (LDM) & open field test (OFT). According to Rajesh KG (2011): The purpose of this study was to characterize the putative phytoconstituents present in the ethanolic root extract having anxiolytic activity using an elevated plus-maze (EPM) & light dark transition model.
3. Convulsion, epileptic fit : Plant part used: Root. Documented pharmacological profile: Phénytoïne-like.
   According to Dhayabaran D (2012): The aim of the present study was to evaluate the anticonvulsant effects of alcoholic root extract of Cardiospermum halicacabum L., Sapindaceae (ARECH), on the various murine models of epilepsy. These results suggested that ARECH possesses à significant anticonvulsant activity with à low motor toxicity profile.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

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