Cassia fistula (Kas) : medicinal properties in alcoholic extraction

Cassia fistula (Kas) — family Caesalpiniacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 35 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Type II diabetes mellitus : Plant part used: Bark. Documented pharmacological profile: Metformine-like.
   According to Ayinla (2015): The control & diabetic groups received normal saline while the diabetic treated groups were administered with 5mg/kg & 100mg/kg body weight of Glibenclamide & ethanolic leaves extract of SF respectively for 28 days. Increasing evidence in both experimental & clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. According to Malpani SN (2010): Bark in alloxan induced diabetic rats.
2. Hepatitis, cirrhosis, fatty liver disease : Plant part used: Fruit.
   According to Kalantari H (2017): The protective effect of Cassia fistula fruit extract against liver injury evoked by bromobenzene was confirmed by histological examination as well. In conclusion, the CF fruit extract has significant hepatoprotective effect in our murine model. According to Xie Q (2012): The present study was designed to investigate the hepatoprotective effects of cassia seed ethanol extract (CSE) in carbon tetrachloride (CCl(4))-induced liver injury in mice.
3. Hyperlipidaemia, atherosclerosis : Plant part used: Fruit. Documented pharmacological profile: Atorvastatine-like.
   According to Rizwana Abid (2016): Objective: To investigate the hypolipidemic & antioxidant effects of ethanol extract of CF fruit (CFE) in high-fat diet (HFD) induced hyperlipidemia in mice. Hyperlipidemia is a lipid metabolism disorder & the major risk factor for the development of CVDs. According to Gupta U (2009): Gupta U et al, Study on Hypolipidemic activity of Cassia fistula Linn Legume in Rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Dinesh Valke without modification (CC BY 4.0). License : CC BY 4.0.