Citrus x (Grapefruit) : medicinal properties in alcoholic extraction

Citrus x (Grapefruit) — family Rutacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 3 indications in alcoholic extraction for this species. The monograph draws on 29 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Fruit.
   Selon Chaudhari S (2016) : The plant was found to possess significant analgesic, anti-inflammatory, antioxidant, anthelmintic, antibacterial, antifungal, & hypolipidemic properties. The phytochemical constituents & isolated bioactive compounds of Citrus can be investigated further to develop novel herbal drugs by using reverse pharmacological approaches especially in the treatment of liver diseases, arthritis, malignancies, & other inflammatory diseases. Selon Ahmed OM (2022) : The study suggested that CL & CP fruit peel hydroethanolic extracts have anti-arthritic potentials which may be mediated via their anti-inflammatory activities.
2. Cancer : Plant part used: Fruit.
   Selon Cirmi S (2017) : Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus Medica fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation. Objective: To summarize the numerous evidences on the potential of Citrus juices & their extracts as anticancer agents. Selon El-Kersh DM (2021) : This study aimed at investigating the antitumor potential of the most potent compounds in citrus peels on breast cancer by exploring their anti-estrogenic & anti-aromatase activities.
3. Staphylococcus auricularis : Plant part used: Fruit.
   Selon Adham AN (2015) : From isolated bacterial strain Staphylococcus auricularis showed highest sensitivity against Citrus limon juice with inhibition zone (22mm), in combination with peel (35mm) & Citrus sinensis in combination form showed inhibition zone (19mm). All used citrus fruits showed antimicrobial activity either alone or in combination of peel & juice extracts against isolated bacterial strain. Selon Barreca D (2013) : We also checked the antimicrobial activity of a broad fraction containing all the detected flavonoids obtained by preparative HPLC, in terms of MICs for Staphylococcus aureus.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Forest & Kim Starr without modification (CC BY 4.0). License : CC BY 4.0.