Cordia curassavica (Maho nwè bôd-lanmè) : medicinal properties in alcoholic extraction

Cordia curassavica (Maho nwè bôd-lanmè) — family Boraginacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The monograph draws on 27 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Inflammatory conditions : Plant part used: Sheet. Documented pharmacological profile: Naproxène-like.
   According to Bodini RB (2020): The ODFs showed good antioxidant activity & high anti-inflammatory capacity with inhibition of COX-2 enzyme. The stability study demonstrated the conservation of flavonoids & also the maintenance of the anti-inflammatory capacity of ODFs. According to Roldao EF (2008): Cordia verbenacea is a medicinal plant popularly used in Brazil as anti-inflammatory, antiulcer & anti-rheumatic agent without detailed pharmacological & toxicological studies.
2. Cancer : Plant part used: Sheet.
   According to Parisotto E (2012): Antitumor in vitro assays were performed for both extracts & the results demonstrate that the supercritical extract causes superior reduction in tumor cells viability & proliferation, whereas the most probable type of cell death is apoptosis. The present study aims to provide a comparative evaluation of the antitumor activity from Cordia verbenacea extracts obtained by supercritical fluid extraction (SFE) with CO2 at 300 bar & 50 °C & by classical organic solvent extraction (CE) with ethanol.
3. Sun exposure, UVB radiation on the skin : Plant part used: Sheet.
   According to Melo CBP (2021): CVE (10–100 mg per kg, 30 min before & immediately after UVB exposure) treatment was performed by gavage in hairless mice. Concluding, CVE downregulates the skin inflammatory & oxidative damages triggered by UVB, demonstrating its potentialities as a therapeutic approach,. According to Melo CBP (2021): CVE also regulated epidermal thickening and sunburn cells, reduced dermal mast cells, & preserved collagen integrity.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Marcia Stefani without modification (CC BY 2.0). License : CC BY 2.0.