Cryptostegia grandiflora (Purple Alamanda) : medicinal properties in alcoholic extraction

Cryptostegia grandiflora (Purple Alamanda) — family Apocynacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The monograph draws on 24 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Sheet. Documented pharmacological profile: Indometacine-like.
   According to Albuquerque TM (2009): CgLP-induced inflammation was observed in peritonitis, paw edema & air push models. Cimetidine was effective only in the initial phase of edema. According to Castro JP (2014): This mechanisms & its antioxidant activity could contribute, at least in part, to the anti-inflammatory effect showed by this plant.
2. Oxidative stress : Plant part used: Sheet. Documented pharmacological profile: acide ascorbique-like.
3. Cancer : Plant part used: Root.
   According to El Zalabani S (2003): Cytotoxic activity was determined using Ehrlich ascites carcinoma (EAC) cell-line, in vitro. According to DOSKOTCH W (1972): An alcoholic extract of the aboveground parts of Cryptostegia grandiflora showed inhibitory activity against the KB cell culture & was fractionated through a series of partitions & column chromatography to yield five cardenolides: oleandrigenin, 16-propionylgitoxigenin-a new natural product, 16-anhy drogitoxigenin, gitoxigenin, & rhodexin B,.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by A.J.T. Johnsingh without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.