Cucurbita pepo (Kourjèt) : medicinal properties in alcoholic extraction

Cucurbita pepo (Kourjèt) — family Cucurbitacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The monograph draws on 89 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Disorders caused by exposure to uranium : Plant part used: Seed.
   According to NEAMAH GAK (2023): Results: Showed significantly (p ≥ 0.001) elevated malondialdehyde levels in the GII group (6.19 ± 0.4), while GIII & GIV showed no significant differences. According to Almohaimeed HM (2021): The CP extract alleviated CUMS-induced adrenal histopathological changes & significantly reduced apoptosis (p < 0.001) & significantly upregulated antioxidant levels in the serum. Behavioral changes, corticosterone level, pro-inflammatory cytokines TNF-& IL-6, & oxidant/antioxidant profile were assessed in the serum at the end of the experiment.
2. Cancer : Plant part used: Sheet. Documented pharmacological profile: Taxus baccata-like, CISPLATINE-like.
   According to Dakeng S (2012): Documented data demonstrate that cucurbitacins possess strong pharmacological properties, such as antitumor, anti-inflammatory, & hepatoprotective effects, etc. The aim was to systematically analyze their bioactivities with an emphasis on their anticancer effects. According to Makni M (2008): Hypolipidemic & hepatoprotective effects of flax & pumpkin seed mixture rich in ω-3 & ω-6 fatty acids in hypercholesterolemic rats.
3. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Seed.
   According to Dakeng S (2012): Documented data demonstrate that cucurbitacins possess strong pharmacological properties, such as antitumor, anti-inflammatory, & hepatoprotective effects, etc. According to Agrawal K (2022): Several studies describe the medicinal properties such as anti-diabetic, cardioprotective, anti- depressive, antioxidant, anti-carcinogenic, anti-inflammatory of Pumpkin seeds & seed oil.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Silar without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.