Cuphra ignea (Z§b-sigaràt) : medicinal properties in alcoholic extraction

Cuphra ignea (Z§b-sigaràt) — family Lythracées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The monograph draws on 7 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Hypertension, vasoconstriction : Plant part used: Sheet. Documented pharmacological profile: Lisinopril-like.
   According to El-Kot WMI (2020): CI can be used as a complementary treatment in hypertension & other cardiovascular complications. The results showed its potential to decrease the blood pressure & to restore the changes in ACE & nitric oxide levels in addition to the oxidative stress parameters in L-NAME-induced hypertensive rats. According to Ismail WM (2020): Some Cuphea members are traditionally used in treatment of hypertension.
2. Dyspepsia, gastric ulcer : Plant part used: Aerial parts. Documented pharmacological profile: Ranitidine-like.
   According to Mousa AM (2019): Therefore, the present study was performed to evaluate the gastroprotective effect of aqueous ethanolic extract of CI aerial parts on ethanol-induced gastric ulcer. Conclusions: CI extract showed a potential gastroprotective effect on ethanol-induced gastric ulcer, & its effect may be mediated through suppression of oxidative stress & gastric inflammation.
3. Abnormal serum parameters : Plant part used: Aerial parts.
   According to Ismail WM (2022): Concerning the oxidative stress parameters, both doses displayed significant reduction in malondialdehyde (MDA) level while the high dose restored elevated glutathione level. According to Hassan SK (2019): At the end of the administration period, various parameters were measured in the serum & lung tissues. The results revealed that the oral administration of benzo(a)pyrene resulted in increases in relative lung weight, serum levels of tumor markers (ADA, AHH, & LDH), & the inflammatory marker NF-κB, & a decreased total antioxidant capacity compared with the control.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

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