Datura innoxia (Gwo-Konkonb-chien) : medicinal properties in alcoholic extraction

Datura innoxia (Gwo-Konkonb-chien) — family Solanacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The monograph draws on 42 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Infection : Plant part used: Sheet. Documented pharmacological profile: Ampiciline-like, Gentamycine-like, Ofloxacine-like.
   According to George R (2021): Objective: This research has focused to evaluate the efficacy of Dinoxin B Withanolide against infectious Staphylococcus aureus, including resistant strains. But its antibacterial properties are not yet evaluated. According to Kaushik P (2008): Various parts of Datura innoxia were examined for potential antibacterial activity by preparing their crude aqueous & organic extracts against Gram-negative bacteria (Escherichia coli & Salmonella typhi) & Gram-positive bacteria (Bacillus cereus, Bacillus subtilis & Staphylococcus aureus).
2. Oxidative stress : Plant part used: Sheet. Documented pharmacological profile: Acide ascorbique-like.
3. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Sheet.
   According to Jaafar FR (2018): Jaafar FR et al, Anti-Inflammatory Impacts & Analgesic Activity of Aqueous Extract Datura inoxia Leaves against Induced Pain & Inflammation in Mice. According to WU JT (2022): Furthermore, all withanolides were assessed for their anti-inflammatory activity & results showed that 1 exhibited a fairly good suppression against nitric oxide generation in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 10.33±1.53 μM).

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Dick Culbert trouvé sur https://www.flickr.com/ without modification (CC BY 2.0). License : CC BY 2.0.