Datura metel (Karapat bata) : medicinal properties in alcoholic extraction

Datura metel (Karapat bata) — family Solanacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The monograph draws on 158 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Autoimmune disease : Plant part used: Flower. Documented pharmacological profile: Méthotrexate-like.
   According to Author (2011): Effect of compound Yangjinhua mixture on psoriasis vulgaris. According to Su Y (2017): We isolated seven withasteroids from the flowers of DM & examined their ability to inhibit immune responses in vitro & in vivo. These findings suggest that B2 might mediate the therapeutic effects observed in psoriasis patients following treatment with D.
2. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Methicilline-Streptomycine-like.
   According to Author (2011): The antibacterial efficacy of crude aqueous and ethanol extracts leaf, stem bark and roots of Datura metel at 20mg/ml were assayed against eight clinical bacterial isolates (Streptococcus b hemolytic, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus & Streptococcus dysenteriae) by well in agar method The leaf & stem bark of the plant was antagonistic against the test bacteria species with inhibitory zones of between 35-12 mm while the highest inhibitory zone displayed by one of the reference drug (streptomycin) was 45 mm at 10mg/ml concentration. Among the tested bacterial isolates S aureus was the most inhibited majorly with the ethanol extract. According to Alabri THA (2014): The MTOH crude extract & its derived fractions from dry & fresh leaves showed small & moderate antibacterial potential with one-gram positive (Staphylococcus aureus) & three-gram negative (Escherichia coli, Klebsiella pneumoniae & Pseudomonas aeruginosa) bacteria in the range of 0–17%.
3. Oxidative stress : Plant part used: Sheet.
   According to Mbida H (2022): Survival time & some heart tissue parameters of oxidative stress were recorded in the presence of aqueous extracts of the leaves & seeds of Datura metel. Results: H2O2-enriched Ringer's solution inhibited the negative inotropic & chronotropic effects of acetylcholine, indicating the desensibilization of muscarinic receptors due to H2O2-induced oxidative stress. According to OBOMA YI (2025): Extracts cause cortex & hippocampus neurotoxicity through heightened oxidative stress.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Pancrat without modification (CC BY-SA 3.0). License : CC BY-SA 3.0.