Datura stramonium (Konkond-djab) : medicinal properties in alcoholic extraction

Datura stramonium (Konkond-djab) — family Solanacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 126 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Flower. Documented pharmacological profile: Kanamycine-like, Pénicilline-like, Streptomycine-like, Rifamycine-like, Cefotaxime-like.
   According to Author (2009): In addition to this, these extracts exhibited significant zone of inhibition & good antimicrobial activity against the majority of the selected strains of microorganisms, such as Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger & Fusarium species. (Asclepiadaceae) were evaluated for antimicrobial activity. According to Hadia G (n.d.): The antibacterial activity was checked against Enterobacter (clinical strain/PIMS), Micrococcus luteus (clinical strain/PIMS), Pseudomonas aeruginosa (clinical strain/PIMS), E.coli ATCC 25922, Staphylococcus aureus (clinical strain/PIMS) & Klebsiella pneumonia ATCC 700603.
2. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Ofloxacine-like.
   According to Hadia G (n.d.): The antibacterial activity was checked against Enterobacter (clinical strain/PIMS), Micrococcus luteus (clinical strain/PIMS), Pseudomonas aeruginosa (clinical strain/PIMS), E.coli ATCC 25922, Staphylococcus aureus (clinical strain/PIMS) & Klebsiella pneumonia ATCC 700603. Datura stramonium branches and leaves sample in three different solvents benzene, chloroform & ethanol was extracted & assessed for antibacterial & antifungal activity. According to Author (2009): In addition to this, these extracts exhibited significant zone of inhibition & good antimicrobial activity against the majority of the selected strains of microorganisms, such as Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger & Fusarium species.
3. Diarrhoea : Plant part used: Sheet. Documented pharmacological profile: Atropine-like.
   According to Author (2013): Exp-1 results showed that both DS extract doses caused a dose dependent antidiarrhoeal effect manifested by significant decrease in charcoal intestinal travelling distance & percent (ITP) which is similar to atropine sulphate (0.1 mg/kgBW IP) for the high DS extract dose. While Ex-2 results showed the superiority of DS extract via decreasing the intestinal castor oil enteropooling effect than atropine sulphate (0.3 mg/Kg BW) possibily because the DS extract may have another active mechanism beside its antimuscarinic effect due to its tropane alkaloids content. According to Shrama M (2021): stramonium commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Agnieszka Kwiecień without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.