Dodonea viscosa (Mang-lozèy) : medicinal properties in alcoholic extraction

Dodonea viscosa (Mang-lozèy) — family Sapindacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 98 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Flower. Documented pharmacological profile: Cisplatine-like.
   According to Shafek RE (2015): Its cytotoxic activity against breast carcinoma cell line (MCF7) showed IC50 19.4 μg/ml compared with the standard used (Cisplatin), which its IC50 is 5.48μg/ml. According to CAO S (2009): Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC50 values of 0.79 and 0.70 μM, respectively. This extract, designated MG 3397, showed reproductible cytotoxicity to the A2780 ovarian cancer cell line, with an IC50 value of 6.0 μg/mL.
2. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Glibenclamide-like.
   According to Akhtar MS (2011): Antidiabetic folkloric use of Dodonaea (D.) viscosa leaves was evaluated in normal and alloxan-diabetic rabbits. In addition, synergistic hypoglycemic effects of oral intake of A-M extract (representing 500 mg/kg) along with different doses of insulin were studied in diabetic rabbits. According to Veerapur VP (2010): Veerapur VP et al, Antidiabetic, Hypolipidaemic & antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats, Int J of Phytomed, 2 (2010) 59-70.
3. Fungal infection : Plant part used: Bark. Documented pharmacological profile: Clotrimazole-like.
   According to PATEL M (2008): angustifolia on Candidas albicans from HIV-infected patients. PATEL M et al, Antifungal activity of the plant Dodonea viscosa var. According to Khurram M (2011): Phytochemical screening & in vitro evaluation of anticandidal activity of Dodonaea viscosa (Sapindaceae) The activity of fractions derived from hydroalcoholic extract of D viscosa leaves against Candida albicans (Cl.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

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