Eruphorbia heterophylla (Gwo-Malonmen) : medicinal properties in alcoholic extraction

Eruphorbia heterophylla (Gwo-Malonmen) — family Euphorbiacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The monograph draws on 41 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Helminthiasis : Plant part used: Pest control and veterinary products. Documented pharmacological profile: Albendazole-like.
   According to Nalule AS (2013): Ascaris suum was used for the assays. The study revealed the anthelmintic potential of EH & that water extract was more potent than ethanolic extract. According to Devi A (2014): The results obtained showed that C epigaeus showed the highest anthelmintic activity with death time of 9 minutes at 100 mg/ml concentration.
2. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: ceftriaxone-like, ciprofloxacine-like, gentamicine-like, lincocine-like, ofloxacine-like.
   According to Ughachukwu PO (2014): Materials & methods: Clinical isolates of Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli, & Pseudomonas aeruginosa were incubated in agar plates after serial dilutions (100, 50, 25, 12.5, 6.25, & 3.16 mg/ml) of the extract were added in wells made in the agar & incubated at 37°C. This work evaluated the antibacterial actions of aqueous ethanol leaf extract of Euphorbia heterophylla. According to Author (2014): Antibacterial analysis was carried out using agar well diffusion assay against eight pathogenic strains of gram positive, gram negative bacteria (Neisseria gonorrhea, Salmonella typhi, Pseudomonas aureginosa, Proteus vulgaris, Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia & Bacillus subtillia) & four different fungal species (Aspergillusniger, Aspergillus tamari, Candida albicans & Fusarium oxysporium).
3. Urinary tract infection caused by multidrug-resistant Klebsiella EBSL : Plant part used: Sheet. Documented pharmacological profile: Piperacilline-like, Tazobactum-like. Mentioned synergistic association: Acalypha indica-feuille.
   According to Singh V (2012): Antimicrobial activity of medicinal plants Euphorbia heterophylla & Acalypha indica were assessed for ESBL producing Klebsiella pneumoniae. Enhancement of zone of inhibition of disc of Piperacillin alone towards the disc containing Piperacillin\ Tazobactum, showing a figure of eight impression were considered as ESBL producer. According to Kone JK (2021): Pseudomonas aeruginosa, Pseudomonas aeruginosa NCIB 950 & Candida albicans were sensitive to the cold water a hot water extracts of the plant's parts while chloroform & methanol extracts did not show antimicrobial activities against any of the organisms.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Forest & Kim Starr without modification (CC BY 3.0)[. License : CC BY 3.0.