Humulus lupulus (Hops) : medicinal properties in alcoholic extraction

Humulus lupulus (Hops) — family Cannabacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The monograph draws on 262 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: oxacilline-like, vancomycine-like, linezolid-like.
   Selon Flieger J (2024) : Only the modification of IONPs with DMSO extract improved their antibacterial properties against Gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, Bacillus cereus) from a MIC value of 2.5-10 mg/mL to 0.313-1.25 mg/mL. IONPs are being investigated due to their high potential for antimicrobial activity & lack of toxicity to humans. Selon Karabin M (2016) : Hop oils & resins are well known for their sedative & other neuropharmacological properties, but in addition, these compounds exhibit antibacterial & antifungal effects.
2. Dyspepsia, gastric ulcer : Plant part used: Fruit. Documented pharmacological profile: Ranitidine-like.
   Selon Minaiyan M (2022) : This study was done to evaluate the gastric anti-ulcer capacity of this plant in an animal model. Materials & Methods: Male Wistar rats were used & the gastric ulcer was induced by oral administration of indomethacin (30 mg/kg, p.o.).
3. Fungal : Plant part used: Sheet. Documented pharmacological profile: Tébuconazole-like.
   Selon Karabin M (2016) : Hop oils & resins are well known for their sedative & other neuropharmacological properties, but in addition, these compounds exhibit antibacterial & antifungal effects. Selon Karabin M (2016) : Hop oils & resins are well known for their sedative & other neuropharmacological properties, but in addition, these compounds exhibit antibacterial & antifungal effects.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Luc.T (Buggenhout, België) without modification (CC BY 2.0). License : CC BY 2.0.