Manilkara zapota (Sapotiy) : medicinal properties in alcoholic extraction

Manilkara zapota (Sapotiy) — family Sapotacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The monograph draws on 35 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Type II diabetes mellitus : Plant part used: Fruit. Documented pharmacological profile: Metformine-like.
   Selon Karie PP (2022) : However, for evaluating antidiabetic effects of fractions (chloroform, acetone, ethyl acetate, & remaining ethanol fraction) of EMZFP, diabetes was induced by streptozotocin (60 mg kg-1)-nicotinamide (120 mg kg-1/ml) in differently grouped male rats (n=6). Methods: Antidiabetic effects of EMZFP were assessed in alloxan (150 mg kg-1) induced diabetes in differently grouped rats (n=6). Selon Karie PP (2022) : Thus, the present study aimed to investigate the effects of 70% ethanolic extract of MZ stem bark (EMZSB) in DPPH- and H2O2-scavenging assay, in vitro α-glucosidase inhibition assay, ameliorating diabetes & its complications in alloxan-induced diabetes in Wistar rats.
2. Oxidative stress : Plant part used: stem bark. Documented pharmacological profile: Acide ascorbique-like.
   Selon Aralshood ST (2020) : Furthermore, determination of oxidative stress parameters (malondialdehyde & non-protein sulfhydryls) revealed that LSE treatment mitigated CCl4-triggered modulation of both molecules. LSE also showed a strong antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) & β-carotene-linoleic acid assays. Selon Islam ME (2012) : The present study evaluated the antioxidant activity of cold ethanolic extract of Manilkara zapota (Sapotaceae) leaves.
3. Dyslipidaemia : Plant part used: Fruit. Documented pharmacological profile: Atorvastatine-like.
   Selon Karie PP (2022) : EMZFP-Et & EMZFP-EA fractions depicted a significant improvement in blood glucose, serum lipid profile, cardiovascular risk indices, & peripheral neuropathy. • EMZFP-Et & EMZFP-EA fractions exert potential antihyperglycemic, hypolipidemic effects & significantly improved cardiovascular risk indices, & peripheral neuropathy. Selon DZIB-GUERRA WC (2016) : Formation & accumulation of advanced glycation end-products (AGE) is recognized as a major pathogenic process in diabetic complications, atherosclerosis & cardiovascular diseases.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Daderot without modification (CC0 1.0). License : CC0 1.0.