Morinda cirifolia (Monkey apple) : medicinal properties in alcoholic extraction

Morinda cirifolia (Monkey apple) — family Rubiacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 32 indications in alcoholic extraction for this species. The monograph draws on 184 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Fruit. Documented pharmacological profile: Méthotrexate-like, 5-Fluoro-Uracile-like.
   Selon Cavalcante da Silva G (2016) : The inhibition of tumor growth compared to Ehrlich Carcinoma was more prominent in the dose 200 mg/kg/ip with inhibition percentage of 83.91%, on the other hand against Sarcoma 180. The potential of tumor inhibition was done in vivo against Ehrlich Carcinoma and Sarcoma 180, a Sharp reduction of weight of the tumors was obtained in comparison with the control group. Selon Kumar HC (2022) : citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, & immunomodulatory activities.
2. Allergy, contact dermatitis : Plant part used: Fruit. Documented pharmacological profile: Prednisolone-like.
   Selon Murata K (2014) : Materials & Methods: To investigate the anti-allergic effects of the 50% ethanolic extract of M. Anti-allergic effects of noni have not been reported despite the clinical usage as an anti-allergic agent. Selon Dussossoy E (2016) : The present study was undertaken to evaluate chronic anti-inflammatory & spasmolytic effects of noni juice.
3. Thrombosis, platelet aggregation : Plant part used: Fruit.
   Selon RAMIREZ-BELTRAN R (2015) : Objective: assessing the effects of Noni leaf & fruit extracts on platelet aggregation & blood coagulation, as well as the possible influence of plant age, leaf maturity & extract total phenol & flavonoid contents on it. The in vitro effects of leaf (0,4 and 0,8 mg TSS/mL) & fruit (0,6 & 1,2 mg TSS/mL) extracts on ADP-induced platelet aggregation (PA), prothrombin time (PT) & partial activated thromboplastin time (PATT) in human plasma was determined. Selon Arif Abdul KR (2013) : It works by inhibiting blood from clotting, therefore preventing progression of thrombosis.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Wilfredor without modification (CC0 1.0). License : CC0 1.0.