Morus nigra (Mulberry tree) : medicinal properties in alcoholic extraction

Morus nigra (Mulberry tree) — family Moracées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The monograph draws on 37 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Hyperlipidaemia, hypercholesterolaemia, triglycerides : Plant part used: Sheet. Documented pharmacological profile: Simvastatine-like.
   Selon Yulinah S (2016) : Hyperlipidemia was induced by giving rats a high fat diet along with cholesterol (200 mg/kg), cholic acid (0.2% of chow), and Propylthiouracil (10 mg/kg BW) for 30 days orally. Results: There were significant differences on a group of M200, B50+M100, & B100+M200 compared to the control group at T14, with the value 33.68%, 34.39 %, & 44.81% (in reduction of total cholesterol) & 36.86%, 37.16%, & 49.99% (in reduction of triglyceride). Selon Chen CC (2005) : Chen CC et al, Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits.
2. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Gentamycine-like.
   Selon Al-Dhanani A (2025) : Antimicrobial activities were assessed through the Disk Diffusion Method against selected bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli, & Clostridium botulinum) & fungal strains (Aspergillus flavus, Candida albicans), with inhibition zones measured post-incubation. Therefore, the main objective of this study is to evaluate the mineral content, phytochemical analyses, antifungal & antibacterial properties (for leaves, branches, & roots) of the only mulberry species present in the United Arab Emirates (UAE); Morus nigra (native) & Morus alba (exotic), both of which can be found within the wild flora of Fujairah. Selon Fukai T (2005) : Fukai T et al, Antimicrobial activity of 2-arylbenzofurans from Morus species against methicillin-resistant Staphylococcus aureus.
3. Liver poisoning : Plant part used: Sheet. Documented pharmacological profile: Silymarine-like. Mentioned synergistic association: Méthotrexate.
   Selon Mallhi TH (2014) : Mallhi TH et al, Hepatoprotective activity of aqueous methanolic extract of Morus nigra against paracetamol-induced hepatotoxicity in mice. Selon Gonzalez-Condori EG (2021) : Objective: Evaluate the hepatoprotective effect of Morus nigra hydroalcoholic extract on acetaminophen-induced liver damage in rats. Additionally, a histopathological study was conducted of liver sections.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Wouter Hagens without modification (CC BY 4.0). License : CC BY 4.0.