Nerium oleander (Lôyé-wôz) : medicinal properties in alcoholic extraction

Nerium oleander (Lôyé-wôz) — family Apocynacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The monograph draws on 121 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Flower. Documented pharmacological profile: Chloramphénicol-like.
   Selon Fartyal M (2014) : The present study was designed to evaluate the antibacterial activity of crude extracts of Nerium oleander Crude extracts from different parts (root, stem & leaf) of the plant were extracted using polar (Water & Methanol) & Non-polar (Petroleum ether) solvents & were screened for antibacterial activity by „Disc Diffusion Assay‟ against three Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae & Agrobacterium tumifaciens) & two Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). subtilis found to be the most susceptible organism followed by K. Selon Erwich, E (2010) : Escherichia coli, Pseudomonas aeruginosa & Staphylococcus aureus were used as test bacterial strains.
2. Fungal infection : Plant part used: Flower. Documented pharmacological profile: Nystatine-like.
   Selon Mostaqul Huq (1999) : Mostaqul Huq et al, A novel antibacterial & cardiac steroid from the roots of Nerium oleander. Selon Namian P (2013) : Namian P et al, Screening of Biological Activities (Antioxidant, Antibacterial & Antitumor) of Nerium oleander Leaf & Flower Extracts, Am Jl of Phytomed & CLIN Therapeutics, 1(4), 2013, 378-84,.
3. Cancer : Plant part used: Sheet. Documented pharmacological profile: Cisplatine-like. Mentioned synergistic association: la Cisplatine.
   Selon Block KL (2014) : Cases included 4 colon cancer patients, 3 pancreatic cancer patients (1 neuroendocrine & 2 adenocarcinoma), 1 renal cell carcinoma & 1 lung cancer patient. The renal cell patient experienced tumor regression for 12 months with the extract alone; the 3 pancreatic cancer patients & a colon cancer patient experienced disease stabilization. Selon Wen (2016) : In this review, we compile the phytochemical characteristics & anticancer activity of the cardenolides from this family,.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Alvesgaspar without modification (CC BY-SA 3.0). License : CC BY-SA 3.0.