Peperomia pellucida (Zèb-kouwès) : medicinal properties in alcoholic extraction

Peperomia pellucida (Zèb-kouwès) — family Pipéracées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The monograph draws on 74 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Pénicilline-like.
   Selon Zubair KL (2013) : Ethanol extract of the plant had higher inhibitory action against Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis & Pseudomonas fluorescens. The results of the present study revealed that the leaves of this traditional medicinal plant are a remedy for thrombosis, diarrhoea & possess potential antimicrobial activity against important human pathogens. Selon Ogunmoye AO (2018) : The antimicrobial effects showed it has Minimum Inhibition Concentration (MIC) on Pseudomonas aeruginosa & Bacillus subtilis at 0.01% oil concentration having 7.0 mm and 9.3 mm zones of inhibitions; but MIC against Bacillus cereus was obtained at 0.1% concentration of the oil.
2. Cancer : Plant part used: Aerial parts. Documented pharmacological profile: Zeocine-like.
   Selon Pappachen LK (2013) : the presents study involves in the investigation of various extracts of Peperomia Pellucida for its phytochemical constituents & the cytotoxic potential, Qualitative phytochemical analysis of the plant extracts were done & all the extracts were screened for in vitro cytotoxic activity by MTT assay method using HEK 293 (Human Epithelial Kidney cell line), HeLa (Human cervical cancer cell line) & HePG2 (Human hepatic carcinoma cell line).It was found that the presence of phytochemicals were maximum in the methanol extract of P Pellucida when compared to other extracts and the methanol extract showed significant cytotoxic activity than all the other extracts against the above mentioned cancer cell lines while was found to be less cytotoxic against normal human kidney cells(HEK 293) displaying safety for normal cells. Selon Xu S (2006) : New structures were elucidated mainly by NMR & MS techniques & anticancer activities evaluated in HL-60, MCF-7 & HeLa cell lines. Compound 1 & peperomin E show growth inhibitory effects on the three cancer cell lines with 50-IC values ranging between 1.4 & 9.1 & between 1.8 & 11.1 m-M, respectively.
3. Infections in catfish (Clarias gariepinus) : Plant part used: Pest control and veterinary products. Documented pharmacological profile: Gentamycine-like.
   Selon Awe FA (s.d.) : The identified bacterial pathogen includes Streptococcus sp, Bacillus Cereus, Klebsiella sp, Enterobacter aerogenes and Escherichia coli. The leaves of these plants have inhibitory action on isolated bacteria & can be used to treat bacterial fin-rot of infected catfish Clarias gariepinus. Selon Okoh OS (2017) : Results: The EOs exhibited strong antibacterial activities against six bacteria (Escherichia coli [180], Enterobacter cloacae, Mycobacterium smegmatis, Listeria ivanovii, Staphylococcus aureus, Streptococcus uberis & Vibrio parahaemolyticus) strains.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Navaneeth Krishnan S without modification (CC BY-SA 3.0). License : CC BY-SA 3.0.