Plumeria alba (White frangipani) : medicinal properties in alcoholic extraction

Plumeria alba (White frangipani) — family Plumeriacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 61 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Ciprofloxacine-like.
   Selon Rudrappa M (2022) : Antimicrobial activity was investigated against Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Enterococcus faecalis, Bacillus subtilis, Streptococcus pneumoniae, Candida albicans, & Candida glabrata. These P-AgNPs exhibited potential antimicrobial activity against selected human pathogenic microbes. Selon Khaing W (2019) : Moreover three different solvents such as ethanol, ethyl acetate & n-hexane extracts of the sample were examined for their antimicrobial activities against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus pumilus, Candida albicans & E.
2. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Glibenclamide-like, Glimepiride-like.
   Selon Nanda J (2023) : A Streptozotocin-nicotinamide-induced Type II diabetes model was used to elaborate on the hypoglycemic activity of ethanolic & aqueous leaf extractives of PA which were compared to the diabetic control group. In comparison to the diabetic control group, the ethanolic extract at a dose of 500 mg/kg b.w. Selon Mushtaq A (2017) : Any impairment in the functionality of insulin leads to long lasting metabolic disorder called diabetes mellitus which can be described as a group of disorders i.e., hyperlipidemia, cardiomyopathy, nephritis, fatty liver & weight loss.
3. Oxidative stress : Plant part used: Sheet. Documented pharmacological profile: Acide gallique-like.
   Selon Kadébé T (2016) : Analysis of oxidative stress markers shows that the supernatant fraction & total extract significantly increased serum glutathione level (p < 0.01) but significantly lowered malondialdehyde (MDA) concentration in liver (p < 0.05). Selon Abdulrascheed-Adekele T (2023) : A post-treatment tissue analysis revealed that PAm attenuated neuronal oxidative stress, neuronal inflammation, and neuro-cognitive deficiencies. Consequently, we provide in silico insights into the potential of apigetrin to target AChE/COX-2/NOX/NF-κB Altogether the present study provides preclinical evidence of the therapeutic potential of the apigetrin-enriched PAm extract for treating oxidative stress & neuro-inflammation associated with diabetes.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Basile Morin without modification (CC BY 4.0). License : CC BY 4.0.