Ruellia tuberosa (Pat-kanna) : medicinal properties in alcoholic extraction

Ruellia tuberosa (Pat-kanna) — family Acanthacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The monograph draws on 42 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Type II diabetes mellitus : Plant part used: Aerial parts. Documented pharmacological profile: Pioglitazone-like.
   Selon Ko CY (2018) : The administration of 100 or 400 mg kg BW⁻¹ day⁻¹ of RTL aqueous or ethanolic extracts once a day for 4 weeks significantly ameliorated hyperglycemia, hyperinsulinemia & the insulin resistance (IR) index in diabetic rats. We investigated the effect of RTL aqueous & ethanolic extracts on hypoglycemia in high‐fat diet (HFD) ‐fed plus streptozotocin (STZ) ‐induced T2DM rats, & examined the effect of RTL on glucose uptake in tumor necrosis factor‐α‐induced insulin‐resistant mouse C2C12 myoblasts, a mouse skeletal muscle cell line. Selon Rajan M (2012) : Rajan M et al, Antidiabetic, Antihyperlipidaemic & hepatoprotective activity of methanolic extract of Ruellia tuberosa Linn leaves in normal and alloxan induced diabetic rats, J of Chem & Pharmaceut Res, 2012, 4(6):2860-8.
2. Hypercholesterolaemia, hyperlipidaemia, hypertriglyceridaemia : Plant part used: Root. Documented pharmacological profile: Atorvastatine-like.
   Selon Chaitanya KB (2012) : The present study was designed to investigate the anti- hyperlipidemic activity of Ruella tuberosa ethanolic extract (RTEE 2012) in Triton X-100 induced Hyperlipidemic rats. RTEE 2012 show a significant decrease in the levels of serum cholesterol, triglycerides, LDL, VLDL & significant increase in the level of serum HDL with increase in dose of RTEE 2012 against Triton induced hyperlipidemic rats. Selon Sailaja B (2010) : The extract administration also decreased the extent of lipid peroxidation & enhanced the levels of antioxidant enzymes in the kidneys of urolithic rats, reflecting its antioxidant efficacy against hyperoxaluria induced renal oxidative stress.
3. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Aerial parts. Documented pharmacological profile: Indometacine-like.
   Selon Alam M (2009) : The anti-inflammatory properties exhibited by the extract were comparable to that of indomethacin at a dose of 5 mg/kg (serotonin-induced edema 53.22; egg albumin-induced edema 57.01% inhibition after 4 h). (Acanthaceae) was evaluated for its antinociceptive & anti-inflammatory properties in experimental mice and/or rat models. Selon Kumar RN (2014) : Kumar RN et al, ANTI-INFLAMMATORY ACTIVITY OF TUBER OF RUELLIA TUBEROSA L.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by J.M.Garg without modification (CC BY-SA 3.0). License : CC BY-SA 3.0.