Solanum nigrum (Brèd-morèl) : medicinal properties in alcoholic extraction

Solanum nigrum (Brèd-morèl) — family Solanacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The monograph draws on 97 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Fruit. Mentioned synergistic association: la Doxorubicine.
   Selon Uen WC (2018) : The present study is designed to investigate the anti-oral cancer properties of Solanum nigrum on oral squamous cell carcinoma. These results suggested that AESN has potential to be used as a functional food in adjuvant chemotherapy for treating human oral cancer by suppression of mitochondrial function,. Selon Nawaz A (2022) : The results demonstrated that S.N fractions exhibited anticancer activity against hepatic & cervical cancer cell lines with non-toxic effect in normal cells.
2. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Fruit. Documented pharmacological profile: Diclofénac-like.
   Selon Yeom YE (2019) : Herein, we analyzed the active constituents of SN extract, & evaluated the anti-inflammatory effect on an acute ear edema mouse model. Moreover, SN fruit extract in 80% ethanol on 12-O-tetra-decanoy-lphorbol 13-acetate (TPA)-induced acute ear edema mouse model showed less edema & greater suppression of inflammation than indomethacin, an inflammation inhibitor. Selon Zakaria ZA (2006) : The extract also produced significant (p<0.05) anti-inflammatory & antipyretic activities when assessed using the carrageenan-induced paw edema & brewer's yeast-induced pyrexia tests.
3. Anxiety, nervousness : Plant part used: Fruit. Documented pharmacological profile: Diazépam-like.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Agnieszka Kwiecien without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.