Tectona grandis (Bwa-Tèk) : medicinal properties in alcoholic extraction

Tectona grandis (Bwa-Tèk) — family Verbénacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 23 indications in alcoholic extraction for this species. The monograph draws on 45 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Fruit. Documented pharmacological profile: Ciprofloxacine-like.
   Selon Bitchagno GTM (s.d.) : Isolated compounds as well as crude ethanol extract were tested for their antibacterial activities using broth microdilution method against four Gram negative bacteria strains Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (PA 01), Klebsiella pneumonia (ATCC 11296) & Escherichia aerogenes (ATCC 13048). Among the isolated metabolites, 6-methyl-1,4-dihydroxyanthraquinone exhibited a strong activity against E aerogenes with MIC of 16 μg/mL, while tectograndone showed a moderate activity against E coli with MIC of 32 μg/mL. Selon Kamath K (2017) : Antibacterial activity was carried out by using different concentrations of extracts on bacterial strains of Staphylococcus aureus, Escherichia coli & Pseudomonas aeruginosa by using agar well diffusion method & results were compared.
2. Cancer : Plant part used: Sheet.
   Selon MENEZES (de) FURTADO C (2012) : Over the past six years we have been studying extracts from tropical, specially Amazon, plants, to search for new sensitizers for photodynamic therapy of cancer & infectious diseases. While TGE was highly toxic towards melanoma cells under illumination with red light of the LED, it also possessed significant dark toxicity towards both B16 F10 and murine fibroblast NIH3T3 cells. Selon Prajuabjinda O (2015) : The ethanolic extract of Tectona grandis stem showed the highest cytotoxic activities against human Breast adenocarcinoma (MCF-7), but was less cytotoxic against large cell lung Carcinoma (COR-L23) (IC50 = 3.92 and 7.78 μg/ml, respectively).
3. Osteoarthritis, arthritis, rheumatism, oedema : Plant part used: Shaft. Documented pharmacological profile: Indometacine-like.
   Selon Javalgikar A (2019) : The objective of present study was to evaluate in vitro anti-inflammatory activity & antihelmintic of ethanolic extracts of T grandis leaves. It allays thirst, and acts as antihelmintic, expectorant & anti-inflammatory. Selon Shaik A (2019) : The objective of present study was to evaluate in vitro anti-inflammatory activity & antihelmintic of ethanolic extracts of T grandis leaves.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by SAplants without modification (CC BY 4.0). License : CC BY 4.0.