Areca catechu (Arékié) : medicinal properties in alcoholic extraction

Areca catechu (Arékié) — family Arecacées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The monograph draws on 90 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Type II diabetes mellitus : Plant part used: Seed. Documented pharmacological profile: Acarbose-like.
   According to Ghate R (2014): catechu flowers have shown a significant antidiabetic efficacy in alloxan induced diabetic rats. catechu flowers were administrated orally at the dose of 500 mg/kg for hypoglycemic effect in alloxan induced diabetic rats for 21 d. According to Sahane RS (2013): Diabetes mellitus was induced in rats by High fat diet, high fat emulsion & intraperitoneal injection of Streptozotocin (STZ, 35mg/kg body weight).
2. Oxidative stress : Plant part used: Nuts. Documented pharmacological profile: Acide ascorbique-like.
   According to Sanpinit S (2023): Antioxidant activities were determined using DPPH, ABTS, TPC, TFC, FRAP, NBT, MCA, & ORAC assays. In addition, the SAR analysis indicated that prenyl arabinosyl-(1-6)-glucoside & quinic acid were the primary antioxidant compounds in the Tri-Yannarose extract. According to Sahane RS (2013): It was found that the extract shows significant effects on blood glucose, cholesterol, triglycerides & antioxidant parameters.
3. Cancer : Plant part used: Seed.
   According to Meiyanto (2003): These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition & apoptosis induction. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. According to Sari ML (2017): This study was undertaken to assess the anticancer potential of areca nut extract on human squamous carcinoma (HSC)-3, HSC-2 & human keratinocyte (HaCat) cancer cell lines, and to elucidate the mechanism of its action.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Vinayaraj V R without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.